By   28/09/2026

The Spartans return just 24% of their production, have 48 new players and turn the offense over to Weaver, who has 6 career TD passes against 7 turnover-worthy plays. The Spartans are 10-point favorites at home, per the latest DraftKings Sportsbook odds, and the Over/Under for total points scored is 48.5. While both of these teams are set to meet again later this season, this game will have huge implications for who wins the conference. Michigan State's losses this season have both come against top 10 teams.

Betting on Michigan State football remains a major draw in season through legal wagers on in-state college teams. If the betting line is set at 45 points, these two teams would have to score a combined 46 points or more to produce a winning bet on the OVER. A popular way to bet on the Michigan State vs. Michigan game is using the college football total line for combined points scored. In-state bragging rights are always on the line when those two teams face off against one another each season. The Spartans have won the Big Ten Championship nine times during their tenure in the conference. The highlight of that extended timeframe was the team’s first national title run in that final season.

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'I Will Ride or Die with Anthony Colandrea': Matt Rhule Recaps Nebraska's Loss to Indiana, Previews Oregon

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  • Pat Fitzgerald takes the reins in East Lansing, and he has just a single returning starter.
  • I would also re-check the licence after 15 September because the current entry expires then.
  • The Spartans' lone loss in Big Ten play came against Nebraska on the road earlier this month.
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Let's analyze college football odds around the San Jose State vs. USC odds and make our expert college football picks and predictions for the best bets. That makes sense given this will be the first competitive action for the two overhauled rosters and things could take time to mesh on the offensive side of the ball. Toledo is a +425 third favorite to win the MAC while Michigan State is a +50000 longshot to win the Big Ten. The longtime Northwestern coach — who spent the last three seasons out of the college game following the controversies that ended his tenure in Evanston — brings a ton of Big Ten experience to the job.

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Nebraska and Michigan State are aiming for their first Big Ten Conference wins of the season, as the Spartans fell to USC on Sept. 20, 45-31, while the Huskers dropped to Michigan 30-27. Michigan State is 1-3 against the spread this season but is 1-0 as an underdog. Nebraska failed to cover the point total in its season opener at Arrowhead Stadium against Cincinnati, but did hit the over against Akron (47½ points), Houston Christian (59½ points), and Michigan (47½ points). The Huskers are 3-1 on the season in their over/under history, going a perfect 3-0 at home in point totals. Nebraska's loss to Michigan failed to cover the Nebraska 1½-point underdog line.

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For now, though, all focus remains on the Spartans, a team that is 2-2 (0-1). If Camp Randall Stadium doesn't support this team after they just took down the Nittany Lions, what will it take to get Luke Fickell and Co. back on track? This Week 5 matchup is important for numerous reasons, but none more than the fact that it's UW's 2026 Big Ten home opener. After upsetting Penn State, it comes as no surprise that the Wisconsin Badgers are massive favorites against Michigan State. Stay up to date on all things Huskers by bookmarking Nebraska Cornhuskers On SI, subscribing to HuskerMax on YouTube, and visiting HuskerMax.com daily.

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This top-ranked Notre Dame defense should be able to hold down a Michigan State offense that's only faced Toledo and Eastern Michigan. Notre Dame has only allowed 13 total points to kick off the 2026 season, with all that coming against Wisconsin in Week 1. The Under correlates with backing the Spartans, plus Notre Dame doesn't allow anyone to score, so points should come at a premium in this matchup. With Notre Dame's first two tests coming against Rice and Wisconsin, any top-five ranked team should have won those games by a combined 80 points. My Week 3 college football picks outline why the Spartans should keep it within the 29.5-point spread, even though Notre Dame carries a 97% win probability.

The Spartans, while a soid team, have dropped 2 of their last 4 and nearly fell in the second round in a battle with Louisville. Karaban has scored 49 points in the first 2 games and Reed has 41 points and 40 rebounds in 2 tourney games. F Coen Carr scored a game-high 21 points with 10 rebounds, while G Jeremy Fears Jr. also had a double-double with 12 points and 16 assists.